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Histamine content of the oxyntic mucosa from duodenal ulcer patients: effect of Helicobacter pylori eradication.
- Source :
-
The American journal of gastroenterology [Am J Gastroenterol] 1993 Aug; Vol. 88 (8), pp. 1228-32. - Publication Year :
- 1993
-
Abstract
- The histamine concentration of the oxyntic mucosa was determined in Helicobacter pylori-positive patients with duodenal ulcer before and after antimicrobial therapy and in H. pylori-negative subjects. Determination of serum gastrin was also performed in duodenal ulcer patients before and after H. pylori eradication. The histamine content of the oxyntic mucosa was lower in patients with duodenal ulcer than in H. pylori-negative subjects, but it increased after H. pylori eradication. Conversely, in patients in whom therapy failed to eradicate the microorganism, the histamine content remained unchanged. Serum gastrin levels fell after microorganism eradication, and the percentage of this fall was correlated with the percentage of increase in gastric histamine. In conclusion, our findings suggest that abnormalities of histamine store present in duodenal ulcer patients might be a feature of H. pylori infection.
- Subjects :
- Adult
Amoxicillin therapeutic use
Drug Therapy, Combination therapeutic use
Duodenal Ulcer metabolism
Female
Furazolidone therapeutic use
Gastrins blood
Helicobacter Infections metabolism
Humans
Male
Metronidazole therapeutic use
Time Factors
Duodenal Ulcer microbiology
Gastric Mucosa chemistry
Helicobacter Infections drug therapy
Helicobacter pylori isolation & purification
Histamine analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9270
- Volume :
- 88
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The American journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 8338090