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Carcinoembryonic antigen (CEA) in benign and malignant epithelium of the gall bladder, extrahepatic bile ducts, and ampulla of Vater.
- Source :
-
The Journal of pathology [J Pathol] 1993 May; Vol. 170 (1), pp. 73-6. - Publication Year :
- 1993
-
Abstract
- Carcinoembryonic antigen (CEA) has been reported in benign and malignant epithelium of the gall bladder, although cross-reactivity with CEA-related antigens cannot be excluded. We have investigated the immunoreactivity of three monoclonal and two polyclonal antisera to CEA in benign and malignant epithelium of the gall bladder, extrahepatic bile ducts, and ampulla of Vater. The results varied with the antisera, due to cross-reactivity with CEA-related antigens and according to the epitope specificities. Little CEA was found in benign epithelium using monoclonal antisera or following absorption of a polyclonal antiserum from Dako with human liver powder. The latter was the most reliable at detecting malignant epithelium of the gall bladder and extrahepatic bile ducts. All antisera showed equal immunoreactivity in tumours of the ampulla of Vater. The differences seen in the immunoreactivities between tumours of the upper and lower extrahepatic biliary tract probably indicate a variation in the occurrence of CEA epitopes.
- Subjects :
- Adult
Aged
Aged, 80 and over
Ampulla of Vater immunology
Biliary Tract Diseases immunology
Cholecystitis immunology
Epithelium immunology
Female
Humans
Immunoenzyme Techniques
Male
Middle Aged
Bile Ducts immunology
Biliary Tract Neoplasms immunology
Carcinoembryonic Antigen analysis
Gallbladder immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3417
- Volume :
- 170
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 8326461
- Full Text :
- https://doi.org/10.1002/path.1711700112