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Therapy of severe familial heterozygous hypercholesterolemia by low-density lipoprotein apheresis with immunoadsorption: effects of the addition of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors to therapy.
- Source :
-
The Clinical investigator [Clin Investig] 1993 Nov; Vol. 71 (11), pp. 908-12. - Publication Year :
- 1993
-
Abstract
- To establish whether additional therapy with 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase inhibitors enhances the low-density lipoprotein (LDL) cholesterol lowering effect of LDL apheresis with immunoadsorption in the treatment of patients with familial heterozygous hypercholesterolemia and coronary artery disease we studied eight patients initially on immunoadsorption therapy alone for 3 years. The adding of HMG CoA reductase inhibitors decreased pretreatment LDL cholesterol from 6.76 +/- 0.98 to 4.97 +/- 0.98 mmol/l and posttreatment LDL cholesterol from 2.33 +/- 0.80 to 1.94 +/- 0.67 mmol/l and increased pre- and posttreatment high-density lipoprotein (HDL) cholesterol by 0.08 and 0.13 mmol/l respectively. The LDL/HDL ratio was reduced from 4.0 to 2.8 (prior to any therapy the ratio was 13.4). The increase in LDL cholesterol between weekly treatments was less steep under the combined therapy. At the same time the treated plasma volume during LDL apheresis could be decreased from 5070 +/- 960 to 4370 +/- 1200 ml. We conclude that in patients with severe familial heterozygous hypercholesterolemia LDL apheresis should be combined with HMG CoA reductase inhibitors.
- Subjects :
- Adult
Combined Modality Therapy
Female
Humans
Hyperlipoproteinemia Type II genetics
Immunosorbent Techniques
Male
Middle Aged
Blood Component Removal methods
Heterozygote
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II therapy
Lipoproteins, LDL isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0941-0198
- Volume :
- 71
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Clinical investigator
- Publication Type :
- Academic Journal
- Accession number :
- 8312683
- Full Text :
- https://doi.org/10.1007/BF00185602