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Effect of gamma-irradiated carbohydrates on isolated synaptic membranes.
- Source :
-
Radiation and environmental biophysics [Radiat Environ Biophys] 1993; Vol. 32 (4), pp. 345-55. - Publication Year :
- 1993
-
Abstract
- The effect of gamma-irradiated solutions of carbohydrates, mainly glucose, upon Na+, K(+)-ATPase and lipid peroxidation in rat brain synaptosomal membranes was studied. The membrane damage by irradiated glucose was enhanced in the presence of Fe2+ and was diminished when a free-radical scavenger (BHT) or metal chelators (EDTA, EGTA) were present. It is suggested that a key element in the free-radical membrane damage by irradiated carbohydrates is an Fe(2+)-complex of some species of the radiolysis products. Participation of radiotoxins of carbohydrate origin in radiobiological effects is discussed.
Details
- Language :
- English
- ISSN :
- 0301-634X
- Volume :
- 32
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Radiation and environmental biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 8310129
- Full Text :
- https://doi.org/10.1007/BF01225922