Back to Search
Start Over
Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis.
- Source :
-
Infection and immunity [Infect Immun] 1994 Feb; Vol. 62 (2), pp. 757-8. - Publication Year :
- 1994
-
Abstract
- The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within the N-terminal region of the toxin that affect cytolytic activity.
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 62
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 8300240
- Full Text :
- https://doi.org/10.1128/iai.62.2.757-758.1994