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Marked reduction of pancreatic insulin content in male ventromedial hypothalamic-lesioned spontaneously non-insulin-dependent diabetic (Goto-Kakizaki) rats.
- Source :
-
Metabolism: clinical and experimental [Metabolism] 1994 Jan; Vol. 43 (1), pp. 32-7. - Publication Year :
- 1994
-
Abstract
- The effects of ventromedial hypothalamic (VMH) lesions were examined in male and female non-obese non-insulin-dependent diabetic (Goto-Kakizaki [GK]) rats with respect to glucose metabolism and pancreatic insulin content. VMH lesions produced hyperphagia and hyperinsulinemia in both male and female GK rats. In male rats, plasma glucose levels of VMH-lesioned GK rats (22.7 +/- 3.1 mmol/L) were significantly greater than the levels of sham-operated GK rats (10.6 +/- 1.0 mmol/L, P < .001) at 7 weeks after the operation, although there were no differences in these levels between VMH-lesioned and sham-operated groups in Wistar rats. Plasma insulin levels in male VMH-lesioned GK rats tended to be lower at 7 weeks than at 1 week. VMH lesions caused a significant decrease in the pancreatic insulin content of male GK rats (12.0 +/- 2.3 nmol/L/g pancreas) compared with male sham-operated rats (15.8 +/- 1.4 nmol/L/g pancreas, P < .05) 9 weeks postoperatively. In contrast to the results in male rats, female GK rats showed no differences in plasma glucose levels between VMH-lesioned and sham-operated groups at 7 weeks. Female VMH-lesioned GK rats also showed no difference in plasma insulin levels between 1 week and 7 weeks. The pancreatic insulin level of female VMH-lesioned GK rats was unchanged from that of female sham-operated GK rats. The insulin content was significantly greater in the VMH-lesioned Wistar group than in the sham-operated Wistar group, regardless of sex.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Animals
Blood Glucose analysis
Diabetes Mellitus, Experimental physiopathology
Diabetes Mellitus, Type 2 physiopathology
Female
Hyperinsulinism blood
Hyperinsulinism etiology
Hyperinsulinism physiopathology
Hypothalamic Diseases pathology
Hypothalamic Diseases physiopathology
Hypothalamus, Middle pathology
Insulin blood
Insulin metabolism
Male
Pancreas metabolism
Rats
Rats, Wistar
Sex Characteristics
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Type 2 metabolism
Hypothalamic Diseases metabolism
Hypothalamus, Middle physiology
Insulin analysis
Pancreas chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0026-0495
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Metabolism: clinical and experimental
- Publication Type :
- Academic Journal
- Accession number :
- 8289672
- Full Text :
- https://doi.org/10.1016/0026-0495(94)90154-6