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New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1994 Jan 07; Vol. 37 (1), pp. 195-200. - Publication Year :
- 1994
-
Abstract
- We have previously shown that some ellagitannins are potent inhibitors of protein kinase C (PKC). On the basis of this finding, several series of hexahydroxybiphenyl derivatives of ellagic acid were synthesized as simple analogs of these ellagitannins and were evaluated for their inhibitory effect against PKC. Compounds 23 and 26 were found to be potent inhibitors of PKC, while hexakis-(benzyloxy)biphenyl derivatives exhibited weak anti-PKC activity.
- Subjects :
- Biphenyl Compounds pharmacology
Dibenzoxepins pharmacology
Ellagic Acid chemical synthesis
Ellagic Acid chemistry
Ellagic Acid pharmacology
Humans
Molecular Structure
Recombinant Proteins antagonists & inhibitors
Structure-Activity Relationship
Biphenyl Compounds chemical synthesis
Dibenzoxepins chemical synthesis
Ellagic Acid analogs & derivatives
Protein Kinase C antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 8289196
- Full Text :
- https://doi.org/10.1021/jm00027a025