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Lack of influence of aromatase and 5 alpha-reductase inhibition on [3H]imipramine binding in the male rat brain.

Authors :
Sandrini M
Vergoni AV
Bertolini A
Source :
Journal of endocrinological investigation [J Endocrinol Invest] 1993 Oct; Vol. 16 (9), pp. 679-81.
Publication Year :
1993

Abstract

In intact adult male rats an inhibitor of aromatase and an inhibitor of 5 alpha-reductase did not change the characteristics of [3H]imipramine binding sites in cerebral cortex, hypothalamus, and hippocampus. Testosterone, estradiol and dihydrotestosterone prevented the effect of castration on the number of [3H]imipramine binding sites, but had no effect in non-castrated animals. These data suggest that testosterone and its major metabolites, estradiol and dihydrotestosterone, are equally effective with regard to imipramine binding sites.

Details

Language :
English
ISSN :
0391-4097
Volume :
16
Issue :
9
Database :
MEDLINE
Journal :
Journal of endocrinological investigation
Publication Type :
Academic Journal
Accession number :
8282962
Full Text :
https://doi.org/10.1007/BF03348909