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Lack of influence of aromatase and 5 alpha-reductase inhibition on [3H]imipramine binding in the male rat brain.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 1993 Oct; Vol. 16 (9), pp. 679-81. - Publication Year :
- 1993
-
Abstract
- In intact adult male rats an inhibitor of aromatase and an inhibitor of 5 alpha-reductase did not change the characteristics of [3H]imipramine binding sites in cerebral cortex, hypothalamus, and hippocampus. Testosterone, estradiol and dihydrotestosterone prevented the effect of castration on the number of [3H]imipramine binding sites, but had no effect in non-castrated animals. These data suggest that testosterone and its major metabolites, estradiol and dihydrotestosterone, are equally effective with regard to imipramine binding sites.
- Subjects :
- 5-alpha Reductase Inhibitors
Androstenedione pharmacology
Animals
Aromatase Inhibitors
Brain drug effects
Dihydrotestosterone pharmacology
Gonadal Steroid Hormones pharmacology
Male
Rats
Rats, Wistar
3-Oxo-5-alpha-Steroid 4-Dehydrogenase pharmacology
Androstenedione analogs & derivatives
Aromatase pharmacology
Azasteroids pharmacology
Brain metabolism
Dihydrotestosterone analogs & derivatives
Imipramine metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0391-4097
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 8282962
- Full Text :
- https://doi.org/10.1007/BF03348909