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MK-801 inhibits the development of morphine tolerance at spinal sites.
- Source :
-
Brain research [Brain Res] 1993 Oct 29; Vol. 626 (1-2), pp. 332-4. - Publication Year :
- 1993
-
Abstract
- The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 626
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 8281446
- Full Text :
- https://doi.org/10.1016/0006-8993(93)90597-g