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Differential effects of Mandevilla velutina compounds on paw oedema induced by phospholipase A2 and phospholipase C.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1993 Oct 26; Vol. 243 (3), pp. 213-9. - Publication Year :
- 1993
-
Abstract
- This study compares the effect of Mandevilla velutina compounds with some anti-inflammatory drugs against phospholipase A2- and phospholipase C-induced rat hindpaw oedema. Injection of phospholipase A2 (Naja naja, 2.5-20 U/paw) and phospholipase C (Clostridium perfringens, 0.03-0.05 U/paw) caused a dose-and-time-related increase in paw oedema. Compounds MV 8608 (55 mumol/kg) and MV 8612 (32 mumol/kg, i.p.) inhibited phospholipase A2-induced paw oedema without interfering with phospholipase C-induced oedema. Local injection of both M. velutina compounds also partially attenuated the oedema evoked by phospholipases A2 and C. Dexamethasone (1.3 mumol/kg, p.o.) suppressed only phospholipase A2-induced paw oedema, while indomethacin (11 mumol/kg, p.o.) attenuated only the early phase of phospholipase C-induced oedema. By contrast, phenidone (616 mumol/kg, i.p.) inhibited only phospholipase C-induced oedema, while cyproheptadine (31 mumol/kg) and pyrilamine (100 mumol/kg, p.o.) inhibited only phospholipase A2 oedema. Treatment of animals with compound 48/80 markedly suppressed phospholipase A2-induced paw oedema and to a lesser degree the oedema caused by phospholipase C. Our results indicate that there are marked differences regarding the mechanisms underlying the paw oedema responses caused by phospholipase A2 and phospholipase C. In addition, our data show that M. velutina compounds cause potent and long-lasting inhibition of the pro-inflammatory action of phospholipase A2, an effect which may account for their reported anti-inflammatory activities.
- Subjects :
- Animals
Bradykinin antagonists & inhibitors
Cyproheptadine therapeutic use
Dexamethasone therapeutic use
Edema chemically induced
Glycosides isolation & purification
Male
Phospholipases A
Phospholipases A2
Rats
Steroids isolation & purification
Type C Phospholipases
Anti-Inflammatory Agents therapeutic use
Edema prevention & control
Glycosides therapeutic use
Plants, Medicinal chemistry
Steroids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 243
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 8276072
- Full Text :
- https://doi.org/10.1016/0014-2999(93)90177-j