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Novel internal promoter/enhancer of HTLV-I for Tax expression.
- Source :
-
Nucleic acids research [Nucleic Acids Res] 1993 Nov 11; Vol. 21 (22), pp. 5124-9. - Publication Year :
- 1993
-
Abstract
- The transcription initiation signals in retroviruses lie within the long terminal repeat (LTR) sequences. We have found a new transcriptional promoter in a central portion of the genome of human T-cell leukaemia virus type I (HTLV-I). The transcription start site is located just upstream to the ATG codon of the transcriptional trans-activator molecule, tax protein (Tax). The internal promoter may provide a new insight into gene expression of HTLV-I. The mechanism of leukaemogenesis by the defective HTLV-I is also discussed. Furthermore, we have identified two repeats of a novel enhancer sequence AGTTCT, which are located around the initiation site. We call the sequence HIRE (HTLV-I Internal Regulatory Element).
- Subjects :
- Animals
Base Sequence
Cell Line
DNA, Viral
Gene Products, tax biosynthesis
HeLa Cells
Humans
Molecular Sequence Data
Repetitive Sequences, Nucleic Acid
Transcription, Genetic
Enhancer Elements, Genetic
Gene Products, tax genetics
Human T-lymphotropic virus 1 genetics
Promoter Regions, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0305-1048
- Volume :
- 21
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Nucleic acids research
- Publication Type :
- Academic Journal
- Accession number :
- 8255766
- Full Text :
- https://doi.org/10.1093/nar/21.22.5124