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Adrenoceptor coupling mechanisms which regulate salivary secretion during aging.
- Source :
-
Life sciences [Life Sci] 1993; Vol. 53 (25), pp. 1873-8. - Publication Year :
- 1993
-
Abstract
- In parotid slices and membranes from Wistar rats 2, 12 and 24 months old, changes are noted in adrenoceptor-stimulated K+ fluxes, formation of [3H]inositol phosphates ([3H]IPs), cAMP production, and membrane environment. Norepinephrine-stimulated K+ efflux and formation of [3H]IPs in the slices proceed through an alpha 1-adrenergic mechanism and are reduced 20% and 40% during aging, respectively. In beta-adrenoceptor stimulation with isoproterenol, no age changes were observed in K+ influx and cAMP production. The cholesterol content in membranes was reduced with age; concomitantly, the membrane viscosity decreased with age. These results indicate that the alterations in the membrane environment may provide age-dependent modulation of alpha 1-adrenoceptor coupling mechanisms and their functions.
- Subjects :
- Animals
Cell Membrane physiology
Cyclic AMP metabolism
In Vitro Techniques
Inositol Phosphates metabolism
Parotid Gland growth & development
Phospholipids metabolism
Potassium metabolism
Rats
Rats, Wistar
Receptors, Adrenergic, alpha-1 drug effects
Receptors, Adrenergic, beta drug effects
Salivary Proteins and Peptides metabolism
Viscosity
Aging physiology
Isoproterenol pharmacology
Norepinephrine pharmacology
Parotid Gland physiology
Receptors, Adrenergic, alpha-1 physiology
Receptors, Adrenergic, beta physiology
Saliva metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 53
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 8255147
- Full Text :
- https://doi.org/10.1016/0024-3205(93)90026-y