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Selligueain A, a novel highly sweet proanthocyanidin from the rhizomes of Selliguea feei.
- Source :
-
Journal of natural products [J Nat Prod] 1993 Sep; Vol. 56 (9), pp. 1532-8. - Publication Year :
- 1993
-
Abstract
- Selligueain A, a novel sweet trimeric proanthocyanidin with a doubly linked A unit, has been isolated from the rhizomes of Selliguea feei collected in Indonesia. The structure of this substance was established as epiafzelechin-(4 beta-->8, 2 beta-->O-->7)-epiafzelechin-(4 beta-->8)-afzelechin [1], on the basis of a combination of spectral and chemical methods. The compound was not acutely toxic for mice and not mutagenic in a forward mutation assay utilizing Salmonella typhimurium strain TM677. Selligueain A [1] was rated by a taste panel as exhibiting about 35 times the sweetness intensity of a 2% w/v aqueous sucrose solution, and at a concentration of 0.5% w/v in H2O was perceived as pleasant-tasting rather than astringent.
- Subjects :
- Animals
Anthocyanins adverse effects
Anthocyanins pharmacology
Anthocyanins toxicity
Humans
Indonesia
Magnetic Resonance Spectroscopy
Male
Mice
Mutagenicity Tests
Salmonella typhimurium drug effects
Salmonella typhimurium genetics
Sweetening Agents pharmacology
Sweetening Agents toxicity
Taste drug effects
Anthocyanins isolation & purification
Plants, Medicinal chemistry
Proanthocyanidins
Sweetening Agents isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 56
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 8254348
- Full Text :
- https://doi.org/10.1021/np50099a011