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The influence of antigen organization on B cell responsiveness.
- Source :
-
Science (New York, N.Y.) [Science] 1993 Nov 26; Vol. 262 (5138), pp. 1448-51. - Publication Year :
- 1993
-
Abstract
- The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.
- Subjects :
- Animals
Antibodies, Viral immunology
Antibody Affinity
Immunization
Immunoglobulin G biosynthesis
Immunoglobulin M biosynthesis
Lymphocyte Activation
Macrophages, Peritoneal microbiology
Mice
Mice, Transgenic
Neutralization Tests
T-Lymphocytes, Helper-Inducer immunology
Vesicular stomatitis Indiana virus physiology
Antibodies, Viral biosynthesis
B-Lymphocytes immunology
Immune Tolerance
Membrane Glycoproteins
Vesicular stomatitis Indiana virus immunology
Viral Envelope Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 262
- Issue :
- 5138
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 8248784
- Full Text :
- https://doi.org/10.1126/science.8248784