Back to Search
Start Over
Effect of long-term hemodialysis on arterial compliance in end-stage renal failure.
- Source :
-
Nephron [Nephron] 1993; Vol. 65 (2), pp. 249-53. - Publication Year :
- 1993
-
Abstract
- To assess the influence of long-term hemodialysis on arterial compliance, the elastic vessel wall properties of the common carotid artery were determined in 20 normotensive renal transplant recipients (age 44.7 +/- 4.1 years) 8-12 weeks after first transplantation and in 10 healthy controls (age 45.9 +/- 5.2 years). Arterial distension was measured by using a multigate pulsed Doppler system, blood pressure curve was recorded by finger-plethysmography. 10 patients with a prior long-term hemodialysis of 51 +/- 11 months were compared to 10 patients with a prior short hemodialysis of 18 +/- 7 months. The patients and controls had been matched in respect of age, sex and blood pressure. In the long and short-term hemodialysis group, the proportion of patients (n = 10) with a history of mild hypertension was similar--mild hypertension for 25 +/- 10 months (n = 5) and for 27 +/- 9 months (n = 5). In the group with long-term hemodialysis, the cross-sectional compliance and the distensibility coefficient was significantly reduced in comparison to the group with short-term hemodialysis (p < 0.005) and to the control group (p < 0.001). A significant inverse correlation between the hemodialysis period and the distensibility coefficient (r = -0.59; p < 0.005) showed a decrease in arterial compliance with the length of hemodialysis treatment. The results demonstrate that vessel wall elasticity decreases with the length of hemodialysis treatment and is reduced by hemodialysis-dependent factors, which are detached from sustained arterial hypertension. As cause of reduced arterial compliance in long-term hemodialysis hypervolemia, hypercirculation and disturbed calcium-phosphate metabolism is suggested.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adult
Compliance
Elastic Tissue anatomy & histology
Elastic Tissue physiology
Female
Humans
Kidney Failure, Chronic therapy
Kidney Transplantation
Male
Middle Aged
Time Factors
Carotid Artery, Common anatomy & histology
Carotid Artery, Common physiology
Kidney Failure, Chronic physiopathology
Renal Dialysis adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1660-8151
- Volume :
- 65
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nephron
- Publication Type :
- Academic Journal
- Accession number :
- 8247188
- Full Text :
- https://doi.org/10.1159/000187483