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Evaluation of soluble tumor necrosis factor (TNF) receptors and TNF receptor antibodies in patients with systemic lupus erythematodes, progressive systemic sclerosis, and mixed connective tissue disease.
- Source :
-
Journal of clinical immunology [J Clin Immunol] 1993 Sep; Vol. 13 (5), pp. 321-8. - Publication Year :
- 1993
-
Abstract
- Two TNF binding proteins have been characterized as soluble fragments of TNF receptors. We measured the plasma concentrations of soluble type A (p75) and type B (p55) TNF receptors in patients with systemic lupus erythematodes (SLE), progressive systemic sclerosis (PSS), and mixed connective tissue disease (MCTD). In SLE and PSS patients plasma concentrations of both types of TNF receptors and in MCTD patients type A TNF receptors were significantly elevated compared to controls. Plasma concentrations of both soluble TNF receptors were highly correlated in SLE, PSS, and MCTD patients, indicating a possible coregulation of both TNF receptors. In contrast, soluble interleukin 2 receptor (sCD 25) plasma concentrations were not correlated and seem to be an independent parameter. The soluble forms of the TNF receptors neutralize TNF in cytotoxicity assays and are functionally active as TNF antagonists. In one patient with SLE, autoantibodies against type A TNF receptors were detected, TNF alpha, and TNF beta did not interfere with the autoantibody binding to the receptor.
- Subjects :
- Autoimmune Diseases blood
Cytotoxicity, Immunologic
Humans
Lupus Erythematosus, Systemic blood
Mixed Connective Tissue Disease blood
Receptors, Interleukin-2 analysis
Receptors, Tumor Necrosis Factor analysis
Scleroderma, Systemic blood
Solubility
Tumor Necrosis Factor-alpha physiology
Autoantibodies blood
Autoimmune Diseases immunology
Lupus Erythematosus, Systemic immunology
Mixed Connective Tissue Disease immunology
Receptors, Tumor Necrosis Factor immunology
Scleroderma, Systemic immunology
Tumor Necrosis Factor-alpha antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0271-9142
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8245178
- Full Text :
- https://doi.org/10.1007/BF00920240