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Thrombogenic factors are related to urinary albumin excretion rate in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients.
- Source :
-
Diabetologia [Diabetologia] 1993 Oct; Vol. 36 (10), pp. 1045-50. - Publication Year :
- 1993
-
Abstract
- Parameters of haemostasis, endothelial cell markers and lipid peroxide levels were studied in 64 Type 1 (insulin-dependent) and 94 Type 2 (non-insulin-dependent) diabetic patients according to their urinary albumin excretion rate in comparison with age-matched control subjects. We determined plasma levels of fibrinogen (Clauss' method), coagulation factor VII:activity (clotting assay), factor VII antigen, protein C and S antigen, von Willebrand factor antigen, D-dimer concentration (ELISA), and lipid peroxide levels (thiobarbituric acid) in relation to urinary albumin excretion rate (RIA). Significant positive correlations were found between urinary albumin excretion rate and plasma fibrinogen (p < 0.005, p < 0.02), factor VII activity (p < 0.0002, p < 0.002), factor VII antigen (p < 0.0001, p < 0.001), protein C (p < 0.003, p < 0.05), and lipid peroxides (p < 0.02, p < 0.004) in Type 1 as well as in Type 2 diabetes. Von Willebrand factor (p < 0.001) and protein S (p < 0.0005) correlated with albuminuria only in patients with Type 1 diabetes. Although most of the haemostatic abnormalities are already found in normoalbuminuric patients, the significant positive correlations to urinary albumin excretion indicate that endothelial cell damage and coagulation disorders deteriorate with the progression of diabetic nephropathy.
- Subjects :
- Adult
Aged
Biomarkers blood
Biomarkers urine
Diabetes Mellitus, Type 2 blood
Enzyme-Linked Immunosorbent Assay
Factor VII analysis
Female
Fibrinogen analysis
Humans
Lipid Peroxides blood
Male
Middle Aged
Protein C analysis
Protein S analysis
von Willebrand Factor analysis
Albuminuria
Blood Coagulation Factors analysis
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 urine
Diabetes Mellitus, Type 2 urine
Subjects
Details
- Language :
- English
- ISSN :
- 0012-186X
- Volume :
- 36
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 8243853
- Full Text :
- https://doi.org/10.1007/BF02374497