Detection and characterization of mupirocin resistance in Staphylococcus aureus.

Authors :: Janssen DA
Zarins LT
Schaberg DR
Bradley SF
Terpenning MS
Kauffman CA
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1993 Sep; Vol. 37 (9), pp. 2003-6.
Publication Year :: 1993
Abstract: Fourteen mupirocin-resistant Staphylococcus aureus strains were isolated over 18 months; 12 exhibited low-level resistance, while two showed high-level resistance. Highly mupirocin-resistant strains contained a large plasmid which transferred mupirocin resistance to other S. aureus strains and to Staphylococcus epidermidis. This plasmid and pAM899-1, a self-transferable gentamicin resistance plasmid, have molecular and biologic similarities.

Subjects :: Conjugation, Genetic
DNA, Bacterial isolation & purification
Drug Resistance, Microbial
Electrophoresis, Polyacrylamide Gel
Humans
Microbial Sensitivity Tests
Phenotype
Plasmids
Staphylococcal Infections microbiology
Staphylococcus aureus genetics
Staphylococcus epidermidis drug effects
Staphylococcus epidermidis genetics
Mupirocin pharmacology
Staphylococcus aureus drug effects

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