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Effect of PSK, a protein-bound polysaccharide preparation, on liver tumors of Syrian hamsters induced by Thorotrast injection.
- Source :
-
Acta pathologica japonica [Acta Pathol Jpn] 1993 Sep; Vol. 43 (9), pp. 475-80. - Publication Year :
- 1993
-
Abstract
- The contrast medium Thorotrast, an agent well known to be carcinogenic, was injected into 400 congeneic Syrian hamsters. The resulting incidence of malignant hepatic tumors such as cholangiocarcinoma, hepatocellular carcinoma and hemangiosarcoma, was significantly higher in the male experimental group than in the control group, and the 50% survival period in the male group was shortened by about 100 days (P < 0.01). However administration of the antitumor drug PSK (Polysaccharide Kureha), a protein bound-polysaccharide extracted from basidiomycete fungi, prevented this carcinogenic effect. The incidence of malignant hepatic tumors in the experimental group was 22.5% compared with 2.8% in the control group (P < 0.01) and 10.5% in the PSK-treated group (P < 0.01). PSK also increased the 50% survival period by 61 days (P < 0.01).
- Subjects :
- Animals
Antibiotics, Antineoplastic pharmacology
Carcinoma, Hepatocellular pathology
Carcinoma, Hepatocellular prevention & control
Cholangiocarcinoma pathology
Cholangiocarcinoma prevention & control
Cricetinae
Female
Hemangiosarcoma pathology
Hemangiosarcoma prevention & control
Injections
Liver Neoplasms pathology
Male
Sex Characteristics
Liver Neoplasms chemically induced
Liver Neoplasms prevention & control
Proteoglycans pharmacology
Thorium Dioxide
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6632
- Volume :
- 43
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Acta pathologica japonica
- Publication Type :
- Academic Journal
- Accession number :
- 8237367
- Full Text :
- https://doi.org/10.1111/j.1440-1827.1993.tb01160.x