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Concentration and distribution of heavy metals in nasal mucosa of nickel-exposed workers and of controls, studied with atomic absorption spectrophotometric analysis and with Timm's sulphide silver method.
- Source :
-
Acta oto-laryngologica [Acta Otolaryngol] 1978 Nov-Dec; Vol. 86 (5-6), pp. 449-63. - Publication Year :
- 1978
-
Abstract
- Biopsy specimens from nasal mucosa of 30 nickel-exposed individuals and 6 controls were analysed by atomic absorption spectrophotometry to determine the content of nickel, copper, cobalt, zinc and iron. Timm's sulphide silver staining method was used for visualizing heavy metals in cryostat sections of biopsy material from each individual. The purpose of the investigation was to study the sulphide silver staining pattern in nasal mucosa of nickel-exposed individuals and controls, and to establish whether variations in heavy metal concentrations, especially nickel, affect the histochemical pattern in the mucosa. No consistent differences were found in the histochemical pattern between biopsies with high and low concentrations of nickel or any of the other metals. Some difference in epithelial types between specimens from the nickel-exposed group and the control group was seen, but the staining pattern was quite similar for corresponding epithelial types in the two groups. Two nasal carcinomas from nickel workers were virtually unstained with the sulphide silver staining method.
- Subjects :
- Adult
Aged
Carcinogens
Cobalt metabolism
Copper metabolism
Environmental Exposure
Humans
Iron metabolism
Male
Methods
Middle Aged
Nasal Mucosa pathology
Nickel metabolism
Nose Neoplasms chemically induced
Occupational Diseases chemically induced
Silver
Spectrophotometry, Atomic
Staining and Labeling
Sulfides
Zinc metabolism
Air Pollutants metabolism
Air Pollutants, Occupational metabolism
Metallurgy
Metals metabolism
Nasal Mucosa metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6489
- Volume :
- 86
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Acta oto-laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 82364
- Full Text :
- https://doi.org/10.3109/00016487809107525