The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease.

Authors :: Guridi J
Luquin MR
Herrero MT
Obeso JA
Source :: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 1993 Oct; Vol. 8 (4), pp. 421-9.
Publication Year :: 1993
Abstract: Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.

Subjects :: Animals
Basal Ganglia anatomy & histology
Basal Ganglia physiopathology
Dopamine physiology
Female
Globus Pallidus physiopathology
Haplorhini
Male
Neural Pathways
Parkinson Disease physiopathology
Receptors, Glutamate physiology
Thalamic Nuclei physiopathology
gamma-Aminobutyric Acid physiology
Basal Ganglia surgery
Parkinson Disease surgery
Stereotaxic Techniques
Thalamic Nuclei surgery

Language :: English
ISSN :: 0885-3185
Volume :: 8
Issue :: 4
Database :: MEDLINE
Journal :: Movement disorders : official journal of the Movement Disorder Society
Publication Type :: Academic Journal
Accession number :: 8232351
Full Text :: https://doi.org/10.1002/mds.870080402

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