Back to Search
Start Over
Activity of phenazine analogs against Mycobacterium leprae infections in mice.
- Source :
-
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association [Int J Lepr Other Mycobact Dis] 1993 Sep; Vol. 61 (3), pp. 406-14. - Publication Year :
- 1993
-
Abstract
- Twenty-five compounds structurally related to clofazimine were tested for their ability to inhibit the growth of Mycobacterium leprae using the kinetic method of drug evaluation in the mouse foot pad model of leprosy. Seven of the phenazine derivatives displayed anti-M. leprae activity comparable to that of clofazimine when administered at a concentration of 0.01% (w/w) in the diet. Three of the compounds, B746, B4087, and B4101, were active when administered at 0.001% in the diet. At a dietary concentration of 0.0001%, B4087 and B4101 were slightly more active than clofazimine, while B746 was less active. In the kinetic method of drug evaluation, greater anti-M. leprae activity of phenazine derivatives was generally associated with greater pigmentation of abdominal fat. Of the compounds which did not cause pigmentation when fed at a concentration of 0.01% in the diet B4090 was the most active. This compound also inhibits the growth of a clofazimine-resistant M. smegmatis strain.
- Subjects :
- Abdomen
Adipose Tissue drug effects
Animals
Clofazimine chemistry
Clofazimine pharmacology
Clofazimine therapeutic use
Disease Models, Animal
Drug Evaluation, Preclinical
Female
Humans
Kinetics
Leprosy microbiology
Mice
Molecular Structure
Mycobacterium leprae growth & development
Phenazines chemistry
Phenazines therapeutic use
Pigmentation
Leprosy drug therapy
Mycobacterium leprae drug effects
Phenazines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0148-916X
- Volume :
- 61
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
- Publication Type :
- Academic Journal
- Accession number :
- 8228439