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Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
- Source :
-
FEBS letters [FEBS Lett] 1993 Nov 01; Vol. 333 (3), pp. 311-4. - Publication Year :
- 1993
-
Abstract
- Cloned mouse delta-subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction. Opioid delta-agonists evoked a calcium-dependent chloride current in oocytes injected with mRNA derived from DOR1, together with that from the alpha subunit of Gi1. The delta-agonist-induced current was blocked by naltrindol, a delta-specific antagonist. The delta-agonist evoked no or very weak currents in oocytes with the alpha subunit of Gq or G(o). These findings indicate the functional coupling between the opioid delta-receptor and phospholipase C through an activation of Gi.
- Subjects :
- Animals
Electric Conductivity drug effects
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
Enkephalin, D-Penicillamine (2,5)-
Enkephalin, Leucine analogs & derivatives
Enkephalin, Leucine pharmacology
Enkephalins pharmacology
Enzyme Activation
Female
Gene Expression
Membrane Potentials drug effects
Mice
Naltrexone analogs & derivatives
Naltrexone pharmacology
Narcotic Antagonists pharmacology
Oocytes drug effects
Oocytes metabolism
Pyrrolidines pharmacology
Receptors, Opioid, delta biosynthesis
Receptors, Opioid, delta drug effects
Xenopus laevis
Analgesics pharmacology
Benzeneacetamides
GTP-Binding Proteins metabolism
Oocytes physiology
Receptors, Opioid, delta physiology
Type C Phospholipases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 333
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 8224200
- Full Text :
- https://doi.org/10.1016/0014-5793(93)80677-m