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Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.

Authors :
Miyamae T
Fukushima N
Misu Y
Ueda H
Source :
FEBS letters [FEBS Lett] 1993 Nov 01; Vol. 333 (3), pp. 311-4.
Publication Year :
1993

Abstract

Cloned mouse delta-subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction. Opioid delta-agonists evoked a calcium-dependent chloride current in oocytes injected with mRNA derived from DOR1, together with that from the alpha subunit of Gi1. The delta-agonist-induced current was blocked by naltrindol, a delta-specific antagonist. The delta-agonist evoked no or very weak currents in oocytes with the alpha subunit of Gq or G(o). These findings indicate the functional coupling between the opioid delta-receptor and phospholipase C through an activation of Gi.

Details

Language :
English
ISSN :
0014-5793
Volume :
333
Issue :
3
Database :
MEDLINE
Journal :
FEBS letters
Publication Type :
Academic Journal
Accession number :
8224200
Full Text :
https://doi.org/10.1016/0014-5793(93)80677-m