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Growth and growth hormone in children during and after therapy for acute lymphoblastic leukaemia.
- Source :
-
European journal of pediatrics [Eur J Pediatr] 1993 Sep; Vol. 152 (9), pp. 730-3. - Publication Year :
- 1993
-
Abstract
- Growth impairment and growth hormone (GH) deficiency have been reported in children treated for acute lymphoblastic leukaemia (ALL). We have studied growth and GH secretion in a group of 50 patients, affected by ALL, during a 2- to 5-year period after diagnosis, and in 12 "long-term-survivors". We observed a significant decrease in growth velocity during the 1st year (in particular during the first 6 months) of therapy and a catch-up growth after the end of therapy. "Long-term survivors" did not exhibit a significant reduction of height standard deviation score (SDS), as compared to height SDS at diagnosis. None of the patients showed GH deficiency. Our data indicate that chemotherapy significantly affects growth of patients treated for ALL, whereas radiotherapy-at the doses used in this study-does not induce GH deficiency, at least not within 9 years after diagnosis.
- Subjects :
- Adolescent
Analysis of Variance
Child
Child, Preschool
Female
Follow-Up Studies
Growth radiation effects
Growth Disorders chemically induced
Humans
Infant
Longitudinal Studies
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma physiopathology
Radiotherapy adverse effects
Antineoplastic Combined Chemotherapy Protocols adverse effects
Growth drug effects
Growth Hormone metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0340-6199
- Volume :
- 152
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 8223802
- Full Text :
- https://doi.org/10.1007/BF01953986