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Circadian pharmacodynamics of anticancer therapies.
- Source :
-
Clinical chemistry [Clin Chem] 1993 Nov; Vol. 39 (11 Pt 2), pp. 2413-8. - Publication Year :
- 1993
-
Abstract
- Circadian variation in drug metabolism and tissue sensitivity to drugs affects their activity and toxicity. A growing body of data suggests that therapy may be improved and toxicity reduced by administering antineoplastic agents at carefully selected times of the day. Here I briefly review molecular, cellular, and organismic time-keeping mechanisms as well as cytokinetic, pharmacokinetic, and pharmacodynamic data, which support the predictable and exploitable nonlinear dynamic relation between dose and effect that occurs each day.
- Subjects :
- Animals
Antineoplastic Agents adverse effects
Antineoplastic Agents metabolism
Antineoplastic Agents pharmacokinetics
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Floxuridine administration & dosage
Floxuridine adverse effects
Floxuridine metabolism
Floxuridine pharmacokinetics
Fluorouracil administration & dosage
Fluorouracil metabolism
Fluorouracil pharmacokinetics
Fluorouracil pharmacology
Humans
Antineoplastic Agents administration & dosage
Circadian Rhythm
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9147
- Volume :
- 39
- Issue :
- 11 Pt 2
- Database :
- MEDLINE
- Journal :
- Clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 8222252