Back to Search Start Over

Circadian pharmacodynamics of anticancer therapies.

Authors :
Hrushesky WJ
Source :
Clinical chemistry [Clin Chem] 1993 Nov; Vol. 39 (11 Pt 2), pp. 2413-8.
Publication Year :
1993

Abstract

Circadian variation in drug metabolism and tissue sensitivity to drugs affects their activity and toxicity. A growing body of data suggests that therapy may be improved and toxicity reduced by administering antineoplastic agents at carefully selected times of the day. Here I briefly review molecular, cellular, and organismic time-keeping mechanisms as well as cytokinetic, pharmacokinetic, and pharmacodynamic data, which support the predictable and exploitable nonlinear dynamic relation between dose and effect that occurs each day.

Details

Language :
English
ISSN :
0009-9147
Volume :
39
Issue :
11 Pt 2
Database :
MEDLINE
Journal :
Clinical chemistry
Publication Type :
Academic Journal
Accession number :
8222252