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A tumour-associated antigen expression in human haematological malignancies.
- Source :
-
British journal of haematology [Br J Haematol] 1993 Jul; Vol. 84 (3), pp. 524-6. - Publication Year :
- 1993
-
Abstract
- Objective responses obtained with high-dose in vivo recombinant interleukin 2 (r-IL2) in some leukaemic patients suggest among other hypotheses that blasts might express tumour rejection antigens potentially recognized by cytolytic T lymphocytes. Such antigens have been described in human melanomas and the MAGE-1 gene, coding for a tumour rejection antigen was recently identified. This gene is expressed in various solid tumours, but not in normal cells. We have screened a panel of haematological malignancies by reverse transcription and PCR and we report that MAGE-1 is not expressed in the blasts from 48 patients whereas three cell lines derived from leukaemias express this gene.
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 84
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 8217804
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1993.tb03111.x