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[Plasmatic concentrations of fluoxetine, pharmacokinetics, therapeutic response and side effects].
- Source :
-
Actas luso-espanolas de neurologia, psiquiatria y ciencias afines [Actas Luso Esp Neurol Psiquiatr Cienc Afines] 1993 Jul-Aug; Vol. 21 (4), pp. 143-7. - Publication Year :
- 1993
-
Abstract
- The kinetics of fluoxetine and possible relations between the drug's plasmatic concentration and therapeutic response and side effects were evaluated in a sample of 66 depressive patients, 26 men and 40 women, average age 46.6 years (SD = 14.1), diagnosed according to DSM-III criteria and evaluated using the Hamilton scale for depression (17-item HRSD). We found no difference between plasmatic concentration of fluoxetine in weeks 3 and 6 of treatment, nor in the sum of drug plus active principle in weeks 3 and 6. There was no significant linear correlation between plasmatic concentrations of fluoxetine, norfluoxetine, or the sum of both in weeks 3 and 6 and score on the Hamilton scale in week 6. By means of serial Chi-score calculation we found a "minimum plasmatic concentration" of about 30 ng/ml below which there was less therapeutic response.
- Subjects :
- Adolescent
Adult
Aged
Ambulatory Care
Antidepressive Agents, Tricyclic classification
Antidepressive Agents, Tricyclic therapeutic use
Dose-Response Relationship, Drug
Female
Fluoxetine adverse effects
Hospitals, Psychiatric
Humans
Male
Mental Disorders diagnosis
Mental Disorders metabolism
Middle Aged
Psychiatric Status Rating Scales
Severity of Illness Index
Fluoxetine blood
Fluoxetine pharmacokinetics
Mental Disorders drug therapy
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0300-5062
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Actas luso-espanolas de neurologia, psiquiatria y ciencias afines
- Publication Type :
- Academic Journal
- Accession number :
- 8213289