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MAP kinase is activated during mesoderm induction in Xenopus laevis.
- Source :
-
Developmental biology [Dev Biol] 1994 Jun; Vol. 163 (2), pp. 521-4. - Publication Year :
- 1994
-
Abstract
- MAP kinase (MAPK) is activated in animal cap explants from Xenopus embryos in response to mesoderm induction by FGF. This activation is rapid, appearing within 1 min of treatment with FGF, and prolonged, lasting for at least 2 hr. By immunoblot analysis, this activation of MAPK is coupled with an electrophoretic shift to the slowly migrating, phosphorylated form of MAPK. Activin-stimulated mesoderm induction also results in the activation of MAPK, but only upon prolonged exposure. However, activin can potentiate the activation of MAPK by FGF as early as 1 min after administration. These findings suggest that MAPK is involved in the early signaling events of FGF-mediated mesoderm induction, and this involvement is modulated by other mesoderm inducers such as activin.
- Subjects :
- Amino Acid Sequence
Animals
Embryonic Induction
Enzyme Activation
Fertilization
Fibroblast Growth Factor 2 pharmacology
Mitogen-Activated Protein Kinase 1
Molecular Sequence Data
Ovum enzymology
Peptides chemistry
Peptides immunology
Protein Serine-Threonine Kinases metabolism
Protein-Tyrosine Kinases metabolism
Xenopus laevis embryology
Subjects
Details
- Language :
- English
- ISSN :
- 0012-1606
- Volume :
- 163
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 8200485
- Full Text :
- https://doi.org/10.1006/dbio.1994.1168