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Cytogenetic conversion in a case of polycythaemia vera treated with interferon-alpha.

Authors :
Messora C
Bensi L
Vecchi A
Longo R
Giacobbi F
Temperani P
Bevini M
Emilia G
Sacchi S
Source :
British journal of haematology [Br J Haematol] 1994 Feb; Vol. 86 (2), pp. 402-4.
Publication Year :
1994

Abstract

Polycythaemia vera is a clonal disorder of the haemopoietic stem cell causing a pathologic expansion of the erythroid and sometimes the megakaryocytic and myeloid elements. In order to avoid the possible mutagenic effects of radioactive phosphorus, alkylating agents and hydroxyurea, since 1988 alpha-IFN has been used for the treatment of PV and has been shown to induce and maintain haematological remission. We describe a 24-year-old PV patient with chromosomal abnormalities who achieved not only a reduction of the proliferation of erythroid elements and reticulin content in the bone marrow, but also a complete cytogenetic remission after IFN treatment.

Details

Language :
English
ISSN :
0007-1048
Volume :
86
Issue :
2
Database :
MEDLINE
Journal :
British journal of haematology
Publication Type :
Academic Journal
Accession number :
8199036
Full Text :
https://doi.org/10.1111/j.1365-2141.1994.tb04752.x