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Cytogenetic conversion in a case of polycythaemia vera treated with interferon-alpha.
- Source :
-
British journal of haematology [Br J Haematol] 1994 Feb; Vol. 86 (2), pp. 402-4. - Publication Year :
- 1994
-
Abstract
- Polycythaemia vera is a clonal disorder of the haemopoietic stem cell causing a pathologic expansion of the erythroid and sometimes the megakaryocytic and myeloid elements. In order to avoid the possible mutagenic effects of radioactive phosphorus, alkylating agents and hydroxyurea, since 1988 alpha-IFN has been used for the treatment of PV and has been shown to induce and maintain haematological remission. We describe a 24-year-old PV patient with chromosomal abnormalities who achieved not only a reduction of the proliferation of erythroid elements and reticulin content in the bone marrow, but also a complete cytogenetic remission after IFN treatment.
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 86
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 8199036
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1994.tb04752.x