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Interleukin-1 alpha as an autocrine growth factor for acute lymphoblastic leukaemia cells.
- Source :
-
British journal of haematology [Br J Haematol] 1994 Feb; Vol. 86 (2), pp. 386-8. - Publication Year :
- 1994
-
Abstract
- We describe a case of B-lineage acute lymphoblastic leukaemia (ALL) with proliferation of leukaemic cells through an interleukin-1 alpha (IL-1 alpha) autocrine mechanism. Flow cytometric analysis using the IL-1 receptor type II (IL-1Rt II) monoclonal antibody (mAb) demonstrated the expression of the IL-1Rt II on leukaemic cells: this is the first report in IL-1RtII-positive freshly isolated ALL cells from a patient. In accordance with the expression of IL-1RtII, the leukaemic cells proliferated in response to exogenous IL-1 alpha. In addition, anti-IL-1 alpha mAb markedly inhibited the spontaneous cell proliferation. Furthermore, Northern blot analysis detected IL-1 alpha mRNA without any stimulation. These observations suggest that IL-1 alpha may play an important role as an autocrine growth factor in some cases of ALL.
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 86
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 8199031
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1994.tb04746.x