Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats.

Authors :: Matas AJ
Sutherland DE
Steffes MW
Mauer SM
Sowe A
Simmons RL
Najarian JS
Source :: Science (New York, N.Y.) [Science] 1976 May 28; Vol. 192 (4242), pp. 892-4.
Publication Year :: 1976
Abstract: A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme uridine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.

Subjects :: Animals
Bilirubin blood
Heterozygote
Homozygote
Rats
Transplantation, Homologous
Disease Models, Animal
Glucuronosyltransferase deficiency
Hexosyltransferases deficiency
Hyperbilirubinemia, Hereditary surgery
Liver Transplantation

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