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Relationship of prefrontal and temporal lobe MRI measures to neuropsychological performance in chronic schizophrenia.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1994 Feb 15; Vol. 35 (4), pp. 235-46. - Publication Year :
- 1994
-
Abstract
- This preliminary study focused on the relationship between prefrontal and temporal lobe MRI measures and neuropsychological performance in chronic schizophrenia. Seventeen schizophrenic inpatients received an MRI and a neuropsychological test battery after clinical stabilization, on average 2 months after admission. The central finding was a significant inverse correlation between neurocognitive measures of prefrontal function and dorsolateral prefrontal cortex (DLPFC) area, strongest in the left hemisphere. Neurocognitive performance did not correlate significantly with orbital frontal area or total temporal lobe volume. The correlations of neuropsychological performance with total frontal volume and whole brain volume were generally not significant, although the pattern was similar to that associated with the DLPFC. Because a number of executive-attention and abstraction measures were significantly associated with the DLPFC, dysfunctions of this region may underlie a syndrome of cognitive dysfunctions. Long-term memory functions were also significantly correlated with the DLPFC, raising the possibility that recall memory defects in schizophrenia are, in part, associated with prefrontal contributions of attention, abstract reasoning, and executive function. This study needs replication with a larger sample of patients and more comprehensive volumetric morphometric analyses.
- Subjects :
- Adolescent
Adult
Brain Diseases complications
Brain Diseases physiopathology
Chronic Disease
Cognition Disorders etiology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Prefrontal Cortex diagnostic imaging
Radiography
Schizophrenia diagnosis
Schizophrenia etiology
Sex Factors
Task Performance and Analysis
Temporal Lobe diagnostic imaging
Prefrontal Cortex physiopathology
Schizophrenia physiopathology
Temporal Lobe physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 8186328
- Full Text :
- https://doi.org/10.1016/0006-3223(94)91254-8