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FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions.
- Source :
-
Mechanisms of development [Mech Dev] 1994 Jan; Vol. 45 (1), pp. 15-30. - Publication Year :
- 1994
-
Abstract
- We have isolated cDNA and genomic clones for the murine FGF-7 gene and examined its expression throughout development. Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles. Regional expression was detected in the ventricular zone of the developing forebrain at 14.5 d.p.c. Later in development, FGF-7 RNA was detected in mesenchymal tissues suggesting a role in epithelial-mesenchymal interactions and in the dermis consistent with its proposed role as a keratinocyte mitogen. Our results suggest that FGF-7 is likely to have diverse roles during development.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Cell Communication physiology
Cloning, Molecular
DNA analysis
DNA genetics
Epithelial Cells
Epithelium physiology
Fibroblast Growth Factor 10
Fibroblast Growth Factor 7
Gene Expression Regulation genetics
Growth Substances genetics
Heart embryology
Keratinocytes chemistry
Keratinocytes cytology
Mesoderm physiology
Mice
Molecular Sequence Data
Morphogenesis physiology
Muscles physiology
Prosencephalon physiology
RNA, Messenger analysis
RNA, Messenger genetics
Transcription, Genetic
Fibroblast Growth Factors
Growth Substances physiology
Mesoderm cytology
Mice, Inbred Strains embryology
Muscles embryology
Prosencephalon embryology
Subjects
Details
- Language :
- English
- ISSN :
- 0925-4773
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Mechanisms of development
- Publication Type :
- Academic Journal
- Accession number :
- 8186145
- Full Text :
- https://doi.org/10.1016/0925-4773(94)90050-7