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[Gamma-interferon and the antibacterial activity of mouse macrophages in a Salmonella infection].
- Source :
-
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1994 Jan-Feb (1), pp. 64-9. - Publication Year :
- 1994
-
Abstract
- The influence of natural and recombinant mouse gamma-interferon (gamma-IF) on Salmonella typhimurium was experimentally studied. The preparations of gamma-IF were introduced into animals in a dose of 250 units per mouse according to different schedules before and after Salmonella inoculation. In these experiments the capacity of the animals for survival, the elimination of the infective agent from the body and the functional activity of peritoneal exudate macrophages were studied. Natural and recombinant gamma-IF was found to stimulate the ingestion activity and oxidizing metabolism of macrophages of the infected animals. At the same time the preparations of gamma-IF were not capable of enhancing the intracellular killing of salmonellae and tumor cells. Recombinant gamma-IF did not prevent the lethal outcome of S. typhimurium infection in mice and did not increase the elimination of the infective agent from the body. Natural gamma-IF, when introduced into mice in a dose of 250 units per mouse on days 1, 3 and 6 after Salmonella inoculation, ensured the survival rate of more than 80% of the animals, but did not essentially influence the dynamics of the elimination of the infective agent from the host body.
- Subjects :
- Animals
Cells, Cultured drug effects
Cells, Cultured immunology
Drug Evaluation, Preclinical
Lymphoma, Non-Hodgkin
Macrophages, Peritoneal immunology
Mice
Mice, Inbred CBA
Phagocytosis drug effects
Rats
Recombinant Proteins
Salmonella Infections, Animal immunology
Salmonella Infections, Animal mortality
Time Factors
Tumor Cells, Cultured drug effects
Interferon-gamma administration & dosage
Macrophages, Peritoneal drug effects
Salmonella Infections, Animal therapy
Salmonella typhimurium
Subjects
Details
- Language :
- Russian
- ISSN :
- 0372-9311
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhurnal mikrobiologii, epidemiologii i immunobiologii
- Publication Type :
- Academic Journal
- Accession number :
- 8184617