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[Gamma-interferon and the antibacterial activity of mouse macrophages in a Salmonella infection].

Authors :
Fil'chakov IV
Fil'chakov FV
Spivak NIa
Protsap EI
Ivanenko VK
Source :
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1994 Jan-Feb (1), pp. 64-9.
Publication Year :
1994

Abstract

The influence of natural and recombinant mouse gamma-interferon (gamma-IF) on Salmonella typhimurium was experimentally studied. The preparations of gamma-IF were introduced into animals in a dose of 250 units per mouse according to different schedules before and after Salmonella inoculation. In these experiments the capacity of the animals for survival, the elimination of the infective agent from the body and the functional activity of peritoneal exudate macrophages were studied. Natural and recombinant gamma-IF was found to stimulate the ingestion activity and oxidizing metabolism of macrophages of the infected animals. At the same time the preparations of gamma-IF were not capable of enhancing the intracellular killing of salmonellae and tumor cells. Recombinant gamma-IF did not prevent the lethal outcome of S. typhimurium infection in mice and did not increase the elimination of the infective agent from the body. Natural gamma-IF, when introduced into mice in a dose of 250 units per mouse on days 1, 3 and 6 after Salmonella inoculation, ensured the survival rate of more than 80% of the animals, but did not essentially influence the dynamics of the elimination of the infective agent from the host body.

Details

Language :
Russian
ISSN :
0372-9311
Issue :
1
Database :
MEDLINE
Journal :
Zhurnal mikrobiologii, epidemiologii i immunobiologii
Publication Type :
Academic Journal
Accession number :
8184617