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The rat vasoactive intestinal polypeptide cyclic AMP response element regulates gene transcriptional responses differently in neonatal and adult rat sensory neurons.

Authors :
Dobson SP
Quinn JP
Morrow JA
Mulderry PK
Source :
Neuroscience letters [Neurosci Lett] 1994 Feb 14; Vol. 167 (1-2), pp. 19-23.
Publication Year :
1994

Abstract

We studied the ability of the rat vasoactive intestinal polypeptide (VIP) cyclic AMP responsive element (CRE) to regulate reporter gene expression through a c-fos promoter in rat sensory neurons transfected in culture by plasmid microinjection. The CRE enhanced the synergistic response of the promoter to combined potassium-evoked depolarisation and forskolin treatment in neonatal but not adult rat neurons. This corresponds to endogenous VIP expression which is induced synergistically by the same stimuli in neonatal but not adult rat neurons. We conclude that VIP expression in sensory neurons, which is induced by axotomy in vivo, could be regulated through the CRE.

Details

Language :
English
ISSN :
0304-3940
Volume :
167
Issue :
1-2
Database :
MEDLINE
Journal :
Neuroscience letters
Publication Type :
Academic Journal
Accession number :
8177522
Full Text :
https://doi.org/10.1016/0304-3940(94)91018-9