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Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.
- Source :
-
Journal of natural products [J Nat Prod] 1994 Feb; Vol. 57 (2), pp. 243-7. - Publication Year :
- 1994
-
Abstract
- Betulinic acid [1] and platanic acid [2], isolated from the leaves of Syzigium claviforum, were found to be inhibitors of HIV replication in H9 lymphocyte cells. Evaluation of anti-HIV activity with eight derivatives of 1 revealed that dihydrobetulinic acid [3] was also a potent inhibitor of HIV replication. The C-3 hydroxy group and C-17 carboxylic acid group, as well as the C-19 substituents, contribute to enhanced anti-HIV activity. The inhibitory activity of these compounds against protein kinase C (PKC) was also examined, since a correlation between anti-HIV and anti-PKC activities has been suggested. However, there was no apparent correlation between anti-HIV activity and the inhibition of PKC among these compounds.
- Subjects :
- Antiviral Agents pharmacology
Cells, Cultured
HIV-1 physiology
Humans
Lymphocytes microbiology
Pentacyclic Triterpenes
Protein Kinase C antagonists & inhibitors
Triterpenes pharmacology
Virus Replication drug effects
Betulinic Acid
Antiviral Agents isolation & purification
HIV-1 drug effects
Plants, Medicinal chemistry
Triterpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 57
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 8176401
- Full Text :
- https://doi.org/10.1021/np50104a008