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Dyspepsia in healthy blood donors. Pattern of symptoms and association with Helicobacter pylori.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 1994 May; Vol. 39 (5), pp. 1090-8. - Publication Year :
- 1994
-
Abstract
- Whether Helicobacter pylori is causally linked to dyspepsia remains controversial. The aims of this study were to assess in healthy blood donors the prevalence of dyspepsia and dyspepsia subgroups, determine if H. pylori is associated with different categories of dyspeptic symptoms, and evaluate the association between dyspepsia and nicotine, alcohol, and analgesic use. Consecutive blood donors (N = 180) who had no clinical evidence of organic disease were included. Abdominal symptoms were measured by means of a standardized questionnaire that has been previously validated. Subjects with dyspepsia (defined as pain localized to the upper abdomen) were further subdivided into those with ulcer-like, dysmotility-like, reflux-like, or nonspecific dyspepsia. A total of 65 subjects reported abdominal pain or discomfort during the prior 12 months [36.1%, 95% confidence interval (CI) 29.1-43.1]; 44 subjects (24.4%, 95% CI 18.2-30.7) had dyspepsia. Dysmotility-like, reflux-like, and ulcer-like symptoms were reported by 19.4% (95% CI 13.7-25.2), 17.2% (95% CI 11.7-22.7), and 16.7% (95% CI 11.2-22.1) of subjects with dyspepsia, respectively. Fifty-seven subjects (31.7%, 95% CI 24.9-38.5) were H. pylori positive; 26% of subjects with H. pylori and 24% without H. pylori had dyspepsia (P > 0.50). The seroprevalence of H. pylori was also similar among the different categories of dyspepsia. We conclude that infection with H. pylori is not associated with abdominal complaints in otherwise healthy subjects.
- Subjects :
- Adolescent
Adult
Alcohol Drinking adverse effects
Analgesics adverse effects
Antibodies, Bacterial analysis
Aspirin adverse effects
Colonic Diseases, Functional microbiology
Dyspepsia etiology
Female
Helicobacter Infections diagnosis
Humans
Male
Middle Aged
Risk Factors
Smoking adverse effects
Blood Donors
Dyspepsia microbiology
Helicobacter Infections complications
Helicobacter pylori immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 39
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 8174422
- Full Text :
- https://doi.org/10.1007/BF02087563