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[A study of the mechanism of action of BCG against transitional cell carcinoma of the bladder--the change of TNF-alpha and IL-2 in the serum and urine].
- Source :
-
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology [Nihon Hinyokika Gakkai Zasshi] 1994 Mar; Vol. 85 (3), pp. 466-72. - Publication Year :
- 1994
-
Abstract
- To study the mechanism of action of BCG against transitional cell carcinoma of the bladder from the immunological standpoint, we observed time-course changes in the serum and urine levels of tumor necrosis factor (TNF-alpha) and interleukin-2 (IL-2) before and after an intravesical BCG instillation in 16 patients with superficialis transitional cell carcinoma. Serum TNF-alpha concentrations were roughly constant and lower than normal though there was a slight difference between the values before and after BCG instillation or between the test and control values. TNF alpha secretion in urine was increased irrespective of the time for sampling specimens as compared with the control values sampling, remained unaffected by BCG instillations and was increased in many patients even before BCG instillation, probably due to presence of vesical inflammation. No significant changes were detected regarding serum or urine IL-2 before and after BCG instillation and between the test and control values. Thus, the present study failed to demonstrate the involvement of a direct action of TNF-alpha, activation of immunological cells by IL-2 or its direct action as an anti-tumor effect of intravesical instillation of BCG.
- Subjects :
- Administration, Intravesical
Adult
Aged
BCG Vaccine administration & dosage
Carcinoma, Transitional Cell metabolism
Female
Humans
Male
Middle Aged
Urinary Bladder Neoplasms metabolism
BCG Vaccine therapeutic use
Carcinoma, Transitional Cell therapy
Interleukin-2 metabolism
Tumor Necrosis Factor-alpha metabolism
Urinary Bladder Neoplasms therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0021-5287
- Volume :
- 85
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nihon Hinyokika Gakkai zasshi. The japanese journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 8170078
- Full Text :
- https://doi.org/10.5980/jpnjurol1989.85.466