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Patterns of X chromosome inactivation in haematopoietic cells of female carriers of X linked severe combined immunodeficiency.
- Source :
-
Immunodeficiency [Immunodeficiency] 1993; Vol. 4 (1-4), pp. 263-5. - Publication Year :
- 1993
-
Abstract
- We evaluated the use of methylation analysis at the DXS255 locus as a method for carrier detection in X-linked severe combined immunodeficiency (XSCID). We also investigated the variations of X inactivation patterns in several haematopoietic cell lineages of XSCID carriers, both within and between XSCID pedigrees.
- Subjects :
- B-Lymphocytes chemistry
Dinucleoside Phosphates chemistry
Dinucleoside Phosphates genetics
Female
Genetic Carrier Screening
Genetic Linkage
Granulocytes chemistry
Hematopoietic System chemistry
Hematopoietic System cytology
Humans
Male
Methylation
T-Lymphocytes chemistry
Dosage Compensation, Genetic
Severe Combined Immunodeficiency genetics
X Chromosome
Subjects
Details
- Language :
- English
- ISSN :
- 1067-795X
- Volume :
- 4
- Issue :
- 1-4
- Database :
- MEDLINE
- Journal :
- Immunodeficiency
- Publication Type :
- Academic Journal
- Accession number :
- 8167715