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Carrier detection in X-linked immunodeficiencies. I: A PCR-based X chromosome inactivation assay at the MAOA locus.
- Source :
-
Immunodeficiency [Immunodeficiency] 1993; Vol. 4 (1-4), pp. 209-11. - Publication Year :
- 1993
-
Abstract
- We developed an X chromosome inactivation PCR assay, based on differential methylation of the 5' CpG island of the monoamine oxidase A gene (MAOA), close to a highly polymorphic region just downstream of the first exon. The assay provides a method to determine the carrier status of females from pedigrees with X-linked immunodeficiency diseases (XLID).
- Subjects :
- Agammaglobulinemia genetics
Chromosome Mapping
Dinucleoside Phosphates chemistry
Dinucleoside Phosphates genetics
Dosage Compensation, Genetic
Exons
Female
Genetic Linkage
Humans
Male
Methylation
Monoamine Oxidase genetics
Polymerase Chain Reaction
Severe Combined Immunodeficiency genetics
Wiskott-Aldrich Syndrome genetics
Genetic Carrier Screening methods
Immunologic Deficiency Syndromes genetics
X Chromosome
Subjects
Details
- Language :
- English
- ISSN :
- 1067-795X
- Volume :
- 4
- Issue :
- 1-4
- Database :
- MEDLINE
- Journal :
- Immunodeficiency
- Publication Type :
- Academic Journal
- Accession number :
- 8167702