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Interleukin-6 in multiple myeloma: correlation with disease activity and Ki-67 proliferation index.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 1994 Jan; Vol. 12 (3-4), pp. 265-71. - Publication Year :
- 1994
-
Abstract
- Interleukin-6 (IL-6) is supposed to be a growth factor in multiple myeloma (MM). Applying a bioassay and a modified ELISA, we measured serum IL-6 values in 64 patients with overt MM, seven patients with smouldering myeloma (SMM), 57 patients with monoclonal gammopathy of undetermined significance (MGUS) and 40 healthy volunteers as controls. IL-6 failed to discriminate between MGUS and MM, stage I, whereas comparison of MM, stage I and stage II/III (p = 0.0143), or comparison of stable disease/remission and progressive disease (p < 0.0001) revealed significant differences. Furthermore, we found significantly higher IL-6 values in overt MM compared to SMM (p = 0.0018). Using a Ki67/CD38 immunohistological double staining method we found a significant correlation between proliferation of bone marrow myeloma cells and serum IL-6 values in 15 patients (p = 0.005). These data demonstrate that IL-6 is a parameter of disease activity in MM and, beside its role in tumor biology, may become a valuable supplement to the established risk factors when selecting patients with unfavourable clinical course for more aggressive treatment modalities.
- Subjects :
- Biological Assay
Biopsy
Cell Division
Enzyme-Linked Immunosorbent Assay
Humans
Ki-67 Antigen
Multiple Myeloma immunology
Neoplasm Staging
Paraproteinemias blood
Paraproteinemias immunology
Paraproteinemias pathology
Reference Values
Bone Marrow pathology
Interleukin-6 blood
Multiple Myeloma blood
Multiple Myeloma pathology
Neoplasm Proteins analysis
Nuclear Proteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1042-8194
- Volume :
- 12
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 8167557
- Full Text :
- https://doi.org/10.3109/10428199409059598