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HLA A9 and B15 are associated with the generalized form, but not the localized form, of early-onset periodontal diseases.

Authors :
Shapira L
Eizenberg S
Sela MN
Soskolne A
Brautbar H
Source :
Journal of periodontology [J Periodontol] 1994 Mar; Vol. 65 (3), pp. 219-23.
Publication Year :
1994

Abstract

HLA proteins are genetically determined, and account in part for individual immune response. Several studies have been performed seeking an association between HLA antigens and various forms of periodontitis with no conclusive results. The aim of the present study was to determine the frequency of HLA antigens of patients suffering from the localized (LJP) and the generalized (SGP) forms of early-onset periodontitis (EOP). Twenty-six EOP patients from the same ethnic group were studied in comparison to 113 race-matched controls. The EOP group included 11 LJP and 15 SGP patients. HLA-A9 and B15 antigens were found to be significantly elevated in the patient group. These differences were found to be due to the high frequency of A9 and B15 antigens in the SGP patients, with the LJP patient group showing no significant difference from the control group. The results are in agreement with previous studies in which A9 and B15 were found to be associated with EOP. However, previous studies did not differentiate between the localized and the generalized form of EOP. These results support the hypothesis that the generalized and the localized forms of EOP are under different genetic control.

Details

Language :
English
ISSN :
0022-3492
Volume :
65
Issue :
3
Database :
MEDLINE
Journal :
Journal of periodontology
Publication Type :
Academic Journal
Accession number :
8164115
Full Text :
https://doi.org/10.1902/jop.1994.65.3.219