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Effect of recombinant IL-1 beta and recombinant gamma interferon on septic acute lung injury in mice.
- Source :
-
Chest [Chest] 1994 Apr; Vol. 105 (4), pp. 1241-5. - Publication Year :
- 1994
-
Abstract
- The effect of recombinant human interleukin 1B (IL-1B) and recombinant human gamma interferon (IFN-g), when given prophylactically, in a mouse model of septic acute lung injury was studied. Mice were treated with various doses of IL-1B and IFN-g for 3 consecutive days prior to administration of lipopolysaccharide of Escherichia coli (1 mg/kg given intraperitoneally). To determine the histologic changes occurring after prophylactic administration of such cytokines, a scoring system was assessed. A significant reduction of edema and neutrophil accumulation into the lungs of mice was observed, especially at doses of 100 U per mouse and 10,000 U per mouse of IL-1B and IFN-g, respectively. Prophylactic administration of IL-1B or IFN-g caused histologic changes, including marked reduction of edema and neutrophil accumulation in the interstitial and alveolar spaces. Combined prophylactic administration of IL-1B and IFN-g provoked a marked decrease of neutrophil accumulation into the lungs, but was not accompanied by significant reduction of edema or hemorrhage. These results provide evidence for the beneficial role of IL-1B and IFN-g in the abnormality of septic acute lung injury by reducing inflammatory lesions.
- Subjects :
- Animals
Escherichia coli
Female
Lipopolysaccharides
Lung pathology
Mice
Mice, Inbred Strains
Neutrophils pathology
Pulmonary Edema complications
Pulmonary Edema pathology
Recombinant Proteins
Respiratory Distress Syndrome complications
Respiratory Distress Syndrome pathology
Interferon-gamma administration & dosage
Interleukin-1 administration & dosage
Respiratory Distress Syndrome prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0012-3692
- Volume :
- 105
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chest
- Publication Type :
- Academic Journal
- Accession number :
- 8162754
- Full Text :
- https://doi.org/10.1378/chest.105.4.1241