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Mefloquine level monitoring in patients with multidrug resistant Plasmodium falciparum on the Thai Myanmar border.
- Source :
-
The Southeast Asian journal of tropical medicine and public health [Southeast Asian J Trop Med Public Health] 1993 Sep; Vol. 24 (3), pp. 505-7. - Publication Year :
- 1993
-
Abstract
- A total of 42 patients with uncomplicated falciparum malaria who attended the malaria clinic in Mae Sot, Tak Province were treated with single oral dose of MSP 3 tablets (Fansimef, equivalent to 750 mg of mefloquine) concurrently with primaquine (30 mg). They all contracted the infection from Cambodia. The aim of the study was to monitor the efficacy of MSP 3 tablets for the treatment of this highly multiple drug resistant strains of Plasmodium falciparum in this area. Of the 39 patients included for efficacy assessment, 13 (33.3%) patients had sensitive responses, whereas 15 (38.5%) and 8 (20.5%) had RI and RII types of response, respectively. Melfoquine concentrations on Day-3 after treatment in patients with sensitive and treatment failure groups were comparable; the respective mean (SD) values were 665 (279) and 772 (264) ng/ml.
- Subjects :
- Administration, Oral
Adolescent
Adult
Cambodia
Chromatography, High Pressure Liquid
Drug Combinations
Drug Resistance
Drug Therapy, Combination
Humans
Malaria, Falciparum blood
Malaria, Falciparum parasitology
Male
Mefloquine blood
Mefloquine therapeutic use
Middle Aged
Thailand
Treatment Outcome
Antimalarials blood
Antimalarials therapeutic use
Drug Monitoring
Malaria, Falciparum drug therapy
Mefloquine analogs & derivatives
Primaquine blood
Primaquine therapeutic use
Pyrimethamine blood
Pyrimethamine therapeutic use
Sulfadoxine blood
Sulfadoxine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0125-1562
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Southeast Asian journal of tropical medicine and public health
- Publication Type :
- Academic Journal
- Accession number :
- 8160060