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Periaxin, a novel protein of myelinating Schwann cells with a possible role in axonal ensheathment.
- Source :
-
Neuron [Neuron] 1994 Mar; Vol. 12 (3), pp. 497-508. - Publication Year :
- 1994
-
Abstract
- We report the cloning and subcellular localization of a novel Schwann cell-specific protein of 147 kd that we have named periaxin. Periaxin has a remarkable domain of repetitive pentameric units in the primary sequence. It is expressed in the first uncompacted whorls of membrane that ensheathe the axon, and further synthesis of the protein in the rat sciatic nerve parallels the deposition of myelin. In mature myelin, periaxin colocalizes with the myelin-associated glycoprotein in the cytoplasm-filled periaxonal regions of the sheath but is excluded from compact myelin. We propose that periaxin has a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Membrane Proteins genetics
Membrane Proteins metabolism
Microscopy, Immunoelectron
Molecular Probes genetics
Molecular Sequence Data
Myelin Sheath metabolism
Peripheral Nerves metabolism
Rats
Sciatic Nerve growth & development
Sciatic Nerve metabolism
Sciatic Nerve ultrastructure
Subcellular Fractions metabolism
Axons physiology
Membrane Proteins physiology
Myelin Sheath physiology
Schwann Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 8155317
- Full Text :
- https://doi.org/10.1016/0896-6273(94)90208-9