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Inflammatory response to clostridial vaccines in feedlot cattle.
- Source :
-
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 1994 Feb 01; Vol. 204 (3), pp. 415-9. - Publication Year :
- 1994
-
Abstract
- In 24 individually housed feedlot steers that weighed 275 kg, clostridial vaccines were compared for size of injection site reactions, systemic inflammatory response caused by vaccination, and impact on feed consumption. Vaccines were a bacterin/toxoid containing antigens from multiple clostridial species (7-way), and a Clostridium perfringens type C and D toxoid; sterile physiologic saline solution was used as the control. Injection site reactions were observed in all vaccinated cattle. Differences in size of lesions were found, with cattle given the 7-way vaccine (7-way group) having the largest lesions. The inflammatory-response to vaccination, measured by serum concentration of the acute-phase protein haptoglobin, was significantly (P < 0.05) increased in both vaccinated groups over that of controls. However, the 7-way group had higher postinjection values than did the group given type C and D toxoid. The 7-way group had a significant (P < 0.05) 20% decrease in feed consumption in response to the second injection of vaccine. These findings are indicative of potential negative effects of multiple clostridial vaccinations.
- Subjects :
- Acute-Phase Reaction etiology
Acute-Phase Reaction veterinary
Animals
Bacterial Vaccines administration & dosage
Cattle
Cattle Diseases prevention & control
Clostridium Infections prevention & control
Clostridium Infections veterinary
Eating
Haptoglobins analysis
Immunization, Secondary adverse effects
Immunization, Secondary veterinary
Inflammation etiology
Injections, Subcutaneous adverse effects
Injections, Subcutaneous veterinary
Male
Vaccination adverse effects
Weight Gain
Bacterial Vaccines adverse effects
Cattle Diseases etiology
Clostridium immunology
Inflammation veterinary
Vaccination veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0003-1488
- Volume :
- 204
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 8150699