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Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements.
- Source :
-
Nature [Nature] 1994 Mar 17; Vol. 368 (6468), pp. 249-51. - Publication Year :
- 1994
-
Abstract
- The trkC gene is expressed throughout the mammalian nervous system and encodes a series of tyrosine protein kinase isoforms that serve as receptors for neurotrophin-3 (NT3), a member of the nerve growth factor (NGF) family of neurotrophic factors. One of these isoforms, gp145trkC/TrkC K1, mediates the trophic properties of NT3 in cultured cells. Here we show that homozygous mice defective for TrkC tyrosine protein kinase receptors lack Ia muscle afferent projections to spinal motor neurons and have fewer large myelinated axons in the dorsal root and posterior columns of the spinal cord. These mice display abnormal movements and postures, indicating that NT3/TrkC-dependent sensor; neurons may play a primary role in proprioception, the sense of position and movement of the limbs.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Cell Count
Clone Cells
DNA
Ganglia, Spinal pathology
Heterozygote
Homozygote
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Movement Disorders physiopathology
Mutation
Posture
Proprioception genetics
RNA Splicing
Receptor Protein-Tyrosine Kinases genetics
Receptor, trkC
Receptors, Growth Factor genetics
Spinal Cord pathology
Movement Disorders genetics
Muscles innervation
Neurons, Afferent pathology
Receptor Protein-Tyrosine Kinases physiology
Receptors, Growth Factor physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0028-0836
- Volume :
- 368
- Issue :
- 6468
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 8145824
- Full Text :
- https://doi.org/10.1038/368249a0