Back to Search
Start Over
Biological monitoring and possible health effects in workers occupationally exposed to methyl methacrylate.
- Source :
-
International archives of occupational and environmental health [Int Arch Occup Environ Health] 1993; Vol. 65 (4), pp. 227-32. - Publication Year :
- 1993
-
Abstract
- Monitoring by means of blood and urine analysis for methanol was successfully applied in 32 male workers who were exposed to methyl methacrylate (MMA) monomer at 6 ppm as a geometric mean and at 112 ppm as the maximum. Measurement of time-weighted average (TWA) intensity of the vapor exposure was successfully conducted with a diffusive sampler with activated carbon cloth as an adsorbent. Methanol concentrations in whole blood, serum, and urine samples were measured by headspace gas chromatography. The methanol concentrations in the three biological samples collected at the end of 8-h workshifts related linearly with the TWA MMA vapor concentrations, with correlation coefficients of 0.8-0.9. Quantitative evaluation of MMA in vapor and of methanol in urine suggests that only 1.5% of MMA inhaled will be excreted in urine as methanol. There were no significant clinical symptoms or abnormal hematological or serum biochemical findings at this exposure level, except that some workers complained throat irritation and frequent cough and sputa. The results indicate that biological monitoring by analysis for methanol is sensitive enough to detect MMA exposure at levels at which no serious health effects are to be expected.
- Subjects :
- Adult
Air Pollutants, Occupational adverse effects
Chromatography, Gas
Dose-Response Relationship, Drug
Humans
Male
Metabolic Clearance Rate physiology
Methanol pharmacokinetics
Methylmethacrylate
Methylmethacrylates adverse effects
Middle Aged
Occupational Diseases blood
Pharyngitis blood
Air Pollutants, Occupational pharmacokinetics
Environmental Monitoring methods
Methylmethacrylates pharmacokinetics
Occupational Diseases chemically induced
Occupational Exposure adverse effects
Pharyngitis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0340-0131
- Volume :
- 65
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International archives of occupational and environmental health
- Publication Type :
- Academic Journal
- Accession number :
- 8144232
- Full Text :
- https://doi.org/10.1007/BF00381195