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Clinical trial of sparfloxacin for lepromatous leprosy.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1994 Jan; Vol. 38 (1), pp. 61-5. - Publication Year :
- 1994
-
Abstract
- Nine previously untreated patients with lepromatous leprosy were treated with 200 mg of sparfloxacin daily for 12 weeks to determine whether this drug is bactericidal for Mycobacterium leprae in humans. The efficacy of therapy was monitored both clinically and by measuring changes in morphological index, mouse footpad infectivity, and the radiorespirometric activity of M. leprae organisms obtained from serial biopsy specimens and also by determining titers of phenolic glycolipid-I in serum. Most patients showed clinical improvement within 2 weeks of treatment; this was accompanied by significant reductions in the morphological index, mouse footpad infectivity, and bacillary radiorespirometric activity. After 4 weeks of treatment, all patients had a morphological index of zero and specimens from most patients were noninfectious for mice, while the median decrease in radiorespirometric activity was > 99%. Overall results by the rapid radiorespirometric assay paralleled those of the mouse footpad and morphological index assays. Sparfloxacin given at 200 mg once daily appears to be rapidly bactericidal in humans, with activity similar to that observed in a previous clinical trial with 400 mg of ofloxacin.
- Subjects :
- Adolescent
Adult
Animals
Antigens, Bacterial analysis
Female
Foot microbiology
Glycolipids immunology
Humans
Leprosy, Lepromatous microbiology
Male
Mice
Middle Aged
Mycobacterium leprae drug effects
Mycobacterium leprae metabolism
Oxidation-Reduction
Palmitic Acid
Palmitic Acids metabolism
Spirometry
Anti-Infective Agents therapeutic use
Fluoroquinolones
Leprosy, Lepromatous drug therapy
Quinolones therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 8141581
- Full Text :
- https://doi.org/10.1128/AAC.38.1.61