Back to Search
Start Over
Effect of lead exposure on plasma phenylbutazone levels in rats.
- Source :
-
Indian journal of physiology and pharmacology [Indian J Physiol Pharmacol] 1994 Jan; Vol. 38 (1), pp. 61-2. - Publication Year :
- 1994
-
Abstract
- The effect of lead exposure on phenylbutazone kinetics was studied in rats. The biological half-life (t1/2) of phenylbutazone was determined from the plasma level versus time curve in 3 groups of rats given (i) 10 mg/kg lead orally for 8 weeks (ii) 100 mg/kg single oral dose and (iii) no lead, after oral administration of 100 mg/kg phenylbutazone to all rats. The t1/2 of the drug was found to be 33% lower on chronic lead exposure and 46% higher on acute exposure than in unexposed control rats. This variation in the t1/2 values of the two different groups of rats indicates that probably phenylbutazone metabolism varies with the period of lead exposure.
Details
- Language :
- English
- ISSN :
- 0019-5499
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Indian journal of physiology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 8132249